Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.79 |
| ▸ | NPC1 | O15118 | 8/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.79 |
| ▸ | MAPT | P10636 | 5/20 | 0.79 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.79 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.79 |
| ▸ | RELA | Q04206 | 4/20 | 0.79 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.79 |
| ▸ | RECQL | P46063 | 1/20 | 0.79 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.68 |
| ▸ | HPGD | P15428 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.62 |
| ▸ | TP53 | P04637 | 4/20 | 0.62 |
| ▸ | PKM | P14618 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19660455 | 0.88 | RAB9A (1.00) | RAB9AALDH1A1NPC1KDM4ESMN1; SMN2 | |
| SCHEMBL12848929 | 0.86 | HRH3 (0.65) | RAB9AALDH1A1NPC1KDM4ESMN1; SMN2 | |
| SCHEMBL12848981 | 0.84 | HRH3 (0.62) | RAB9AALDH1A1NPC1KDM4ESMN1; SMN2 | |
| SCHEMBL10545285 | 0.82 | HRH3 (1.00) | RAB9AALDH1A1NPC1KDM4ESMN1; SMN2 | |
| SCHEMBL13325759 | 0.82 | NPC1 (0.73) | RAB9AALDH1A1NPC1KDM4ESMN1; SMN2 | |
| SCHEMBL12848885 | 0.81 | HRH3 (0.59) | RAB9AALDH1A1NPC1KDM4ESMN1; SMN2 | |
| SCHEMBL19660462 | 0.81 | ALDH1A3 (0.67) | RAB9AALDH1A1NPC1KDM4ESMN1; SMN2 | |
| SCHEMBL12726223 | 0.81 | MAPT (0.73) | RAB9AALDH1A1NPC1KDM4ESMN1; SMN2 | |
| SCHEMBL24264982 | 0.80 | RAB9A (0.59) | RAB9AALDH1A1NPC1KDM4ESMN1; SMN2 | |
| SCHEMBL29405506 | 0.80 | RAB9A (0.59) | RAB9AALDH1A1NPC1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116096717-A | Imidazo [1,2-a ] pyridine and [1,2,4] triazolo [1,5-a ] pyridine derivatives as TLR9 inhibitors for the treatment of fibrosis | 百时美施贵宝公司 | 2023-05-09 | — | — | CN | claimed |
| CN-116096717-A | Imidazo [1,2-a ] pyridine and [1,2,4] triazolo [1,5-a ] pyridine derivatives as TLR9 inhibitors for the treatment of fibrosis | 百时美施贵宝公司 | 2023-05-09 | — | — | CN | disclosed |