Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 3/20 | 0.41 |
| ▸ | CDK8 | P49336 | 3/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RHEB | Q15382 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.37 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30310570 | 0.87 | KDM4E (0.48) | KDM4ERHEBIDO1 | |
| SCHEMBL24020812 | 0.87 | KDM4E (0.48) | KDM4ERHEBIDO1 | |
| SCHEMBL30310440 | 0.85 | CYP1A2 (0.44) | KDM4EIDO1FLT3 | |
| SCHEMBL23102527 | 0.85 | CYP1A2 (0.44) | KDM4EIDO1FLT3 | |
| Hydrochloric Acid SCHEMBL29761726 | 0.85 | KDM4E (0.47) | KDM4ERHEBIDO1 | |
| SCHEMBL24112871 | 0.83 | NUDT1 (0.47) | CCNCCDK8NUDT1KDM4ECCNK | |
| SCHEMBL24740112 | 0.81 | MEN1 (0.48) | CCNCCDK8KDM4E | |
| SCHEMBL31092842 | 0.81 | ALDH1A1 (0.52) | KDM4E | |
| SCHEMBL24019765 | 0.80 | NUDT1 (0.47) | NUDT1KDM4E | |
| SCHEMBL3207779 | 0.74 | ALDH1A1 (0.42) | KDM4EFYNCDK2PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161902-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |