Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | CBFB | Q13951 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 4/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | RHEB | Q15382 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15939130 | 1.00 | HRH4 (0.57) | HRH4HTTEGLN1PRKCZF10 | |
| SCHEMBL24020380 | 0.85 | HRH4 (0.58) | HRH4HTTEGLN1PRKCZCBFB | |
| SCHEMBL30310503 | 0.85 | HRH4 (0.58) | HRH4HTTEGLN1PRKCZCBFB | |
| SCHEMBL24020387 | 0.80 | HRH4 (0.56) | HRH4HTTEGLN1PRKCZCBFB | |
| SCHEMBL9587797 | 0.77 | GRIN1 (0.49) | HRH4EGLN1PARP1GRIN1RHEB | |
| SCHEMBL24019958 | 0.76 | HRH4 (0.53) | HRH4HTTEGLN1PRKCZCBFB | |
| SCHEMBL9589893 | 0.74 | HRH4 (0.36) | HRH4F10PARP1RHEBPARP2 | |
| SCHEMBL7152026 | 0.73 | HTR3E (0.57) | HRH4F10HPGDALOX15KMT2A | |
| SCHEMBL5924441 | 0.73 | HTT (0.61) | HRH4HTTEGLN1PRKCZF10 | |
| SCHEMBL8872820 | 0.73 | HTT (0.61) | HRH4HTTEGLN1PRKCZF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161902-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |