Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 5/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.49 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.49 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.49 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 3/20 | 0.34 |
| ▸ | RHEB | Q15382 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9588644 | 0.88 | GRIN1 (0.50) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL9587812 | 0.79 | GRIN1 (0.49) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL9587955 | 0.78 | GRIN2D (0.47) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL30310686 | 0.77 | HRH4 (0.57) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL15939130 | 0.77 | HRH4 (0.57) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL9589893 | 0.76 | HRH4 (0.36) | HRH4PARP1RHEBPARP2 | |
| SCHEMBL9588853 | 0.74 | HRH4 (0.37) | HRH4PARP1RHEBPARP2 | |
| SCHEMBL9588254 | 0.68 | PARP1 (0.40) | PARP1PARP2 | |
| SCHEMBL9587926 | 0.68 | PGK1 (0.36) | HRH4PARP1EGLN1 | |
| SCHEMBL9589180 | 0.68 | GPR17 (0.47) | HRH4RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5216003-A | Antihypoxic, antiischemic agents | G. D. SEARLE & CO. (US) | 1993-06-01 | — | — | US | disclosed |