Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 16/20 | 0.59 |
| ▸ | BTK | Q06187 | 3/20 | 0.53 |
| ▸ | AR | P10275 | 4/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26928997 | 0.92 | CRBN (0.60) | CRBNBTKARDDB1PLK4 | |
| SCHEMBL30692979 | 0.92 | CRBN (0.60) | CRBNBTKARDDB1PLK4 | |
| SCHEMBL24671179 | 0.87 | CRBN (0.64) | CRBNBTKARDDB1ALK | |
| SCHEMBL26929077 | 0.86 | CRBN (0.65) | CRBNBTKARDDB1 | |
| SCHEMBL30692989 | 0.86 | CRBN (0.65) | CRBNBTKARDDB1 | |
| SCHEMBL23301420 | 0.86 | CRBN (0.72) | CRBNARDDB1IKZF2 | |
| SCHEMBL24351880 | 0.85 | CRBN (0.67) | CRBNDDB1IKZF2 | |
| SCHEMBL29681830 | 0.85 | CRBN (0.67) | CRBNDDB1IKZF2 | |
| SCHEMBL24671174 | 0.85 | CRBN (0.60) | CRBNBTKARDDB1PLK4 | |
| SCHEMBL31055547 | 0.85 | CRBN (0.60) | CRBNBTKARDDB1PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4146660-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | Nurix Therapeutics, Inc. (US) | 2023-03-15 | — | — | EP | disclosed |