Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.45 |
| ▸ | DRD3 | P35462 | 4/20 | 0.45 |
| ▸ | DRD4 | P21917 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7989858 | 0.84 | ALDH1A1 (0.48) | OPRM1DRD3DRD4DRD2ALDH1A1 | |
| SCHEMBL24683657 | 0.84 | OPRM1 (0.61) | OPRM1DRD3DRD4DRD2TSHR | |
| SCHEMBL24684840 | 0.84 | OPRM1 (0.41) | OPRM1DRD3DRD4DRD2ALDH1A1 | |
| SCHEMBL8661322 | 0.81 | OPRM1 (0.58) | OPRM1DRD3DRD4DRD2ALDH1A1 | |
| SCHEMBL392176 | 0.80 | KCNN4 (0.55) | OPRM1DRD3DRD4DRD2ALDH1A1 | |
| SCHEMBL4640323 | 0.78 | CHRM2 (0.48) | OPRM1DRD3DRD2ALDH1A1TSHR | |
| SCHEMBL24683697 | 0.74 | OPRM1 (0.54) | OPRM1DRD3DRD4DRD2TSHR | |
| SCHEMBL10769662 | 0.73 | ALDH1A1 (0.46) | ALDH1A1TSHRKMT2ACHRM2CHRM1 | |
| SCHEMBL27517247 | 0.73 | KCNN4 (0.50) | OPRM1ALDH1A1TSHROPRD1CYP2C19 | |
| SCHEMBL11648782 | 0.72 | CYP2C19 (0.46) | ALDH1A1TSHRCYP2C19HIF1AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142657-A1 | USE OF THE PIGD PROTEIN FOR CATALYZING 1,4-ADDITIONS OF 2-OXOALKANOATES TO ALPHA, BETA-UNSATURATED KETONES | Albert-Ludwigs-Universität Freiburg (DE) | 2010-01-13 | — | — | EP | disclosed |
| EP-2059238-A2 | THERAPEUTIC COMPOUNDS FOR DISEASES AND DISORDERS | Myriad Genetics, Inc. (US) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008138450-A1 | USE OF THE PIGD PROTEIN FOR CATALYZING 1,4-ADDITIONS OF 2-OXOALKANOATES TO ALPHA, BETA-UNSATURATED KETONES | ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) | 2008-11-20 | — | — | WO | disclosed |
| WO-2008031034-A2 | THERAPEUTIC COMPOUNDS FOR DISEASES AND DISORDERS | MYRIAD GENETICS, INC. (US) | 2008-03-13 | — | — | WO | disclosed |