Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 4/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14240098 | 0.80 | CTNNB1 (0.40) | ARPOLBKDM4ECTNNB1WNT3A | |
| SCHEMBL764379 | 0.78 | AR (0.45) | ARROCK2NAMPTPARP1 | |
| SCHEMBL31690178 | 0.78 | AR (0.45) | ARCYP1A2L3MBTL1ROCK2NAMPT | |
| SCHEMBL26247290 | 0.78 | AR (0.45) | ARCYP1A2L3MBTL1ROCK2NAMPT | |
| SCHEMBL30319372 | 0.77 | POLB (0.49) | ARKMT2APOLBSMN1; SMN2KDM4E | |
| SCHEMBL30319401 | 0.77 | KDM4E (0.63) | KMT2APOLBCYP1A2SMN1; SMN2KDM4E | |
| SCHEMBL13995824 | 0.77 | KDM4E (0.63) | KMT2APOLBCYP1A2SMN1; SMN2KDM4E | |
| SCHEMBL13145722 | 0.75 | AR (0.43) | ARPOLBROCK2NAMPTPARP1 | |
| SCHEMBL26615075 | 0.74 | AR (0.45) | ARROCK2NAMPTPARP1 | |
| SCHEMBL30319377 | 0.74 | KMT2A (0.38) | KMT2APOLBCYP1A2SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161905-A1 | SUBSTITUTED (PHTHALAZIN-1-YLMETHYL)UREAS, SUBSTITUTED N-(PHTHALAZIN-1-YLMETHYL)AMIDES, AND ANALOGUES THEREOF | Arbutus Biopharma Corporation (CA) | 2023-04-12 | — | — | EP | disclosed |