Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30319378 | 0.90 | POLB (0.52) | POLBALDH1A1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL30319379 | 0.81 | POLB (0.72) | POLBALDH1A1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL30319413 | 0.79 | POLB (0.47) | POLBALDH1A1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL30319337 | 0.77 | AR (0.41) | POLBALDH1A1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL11173101 | 0.77 | SMN1; SMN2 (0.69) | POLBALDH1A1SMN1; SMN2LMNAAR | |
| SCHEMBL30319315 | 0.76 | POLB (0.50) | POLBALDH1A1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL26247290 | 0.73 | AR (0.45) | L3MBTL1ARPARP1 | |
| SCHEMBL31690178 | 0.73 | AR (0.45) | L3MBTL1ARPARP1 | |
| SCHEMBL13180318 | 0.73 | AR (0.52) | POLBALDH1A1SMN1; SMN2LMNAAR | |
| SCHEMBL3810014 | 0.71 | KDM4E (0.58) | POLBALDH1A1SMN1; SMN2KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161905-A1 | SUBSTITUTED (PHTHALAZIN-1-YLMETHYL)UREAS, SUBSTITUTED N-(PHTHALAZIN-1-YLMETHYL)AMIDES, AND ANALOGUES THEREOF | Arbutus Biopharma Corporation (CA) | 2023-04-12 | — | — | EP | disclosed |