Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30319315 | 0.85 | POLB (0.50) | POLBALDH1A1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL30319379 | 0.80 | POLB (0.72) | POLBALDH1A1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL24077092 | 0.80 | POLB (0.47) | POLBALDH1A1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL30319378 | 0.79 | POLB (0.52) | POLBALDH1A1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL30319372 | 0.79 | POLB (0.49) | POLBALDH1A1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL30319377 | 0.74 | KMT2A (0.38) | POLBALDH1A1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL30319369 | 0.74 | KMT2A (0.42) | POLBALDH1A1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL8190554 | 0.70 | KDM4E (0.40) | POLBALDH1A1SMN1; SMN2KMT2AKDM4E | |
| SCHEMBL23792137 | 0.67 | JAK2 (0.50) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL24076910 | 0.65 | TSHR (0.51) | POLBALDH1A1SMN1; SMN2TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161905-A1 | SUBSTITUTED (PHTHALAZIN-1-YLMETHYL)UREAS, SUBSTITUTED N-(PHTHALAZIN-1-YLMETHYL)AMIDES, AND ANALOGUES THEREOF | Arbutus Biopharma Corporation (CA) | 2023-04-12 | — | — | EP | disclosed |