Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 10/20 | 0.38 |
| ▸ | WDR48 | Q8TAF3 | 9/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25792088 | 1.00 | USP1 (0.38) | USP1WDR48PTGS2AKR1C3AKR1C2 | |
| SCHEMBL25248352 | 0.90 | USP1 (0.37) | USP1WDR48PTGS2AKR1C3AKR1C2 | |
| SCHEMBL25792707 | 0.88 | USP1 (0.38) | USP1WDR48PTGS2AKR1C3AKR1C2 | |
| SCHEMBL30320365 | 0.86 | USP1 (0.36) | USP1PTGS2AKR1C3AKR1C2PTGS1 | |
| SCHEMBL25792103 | 0.86 | USP1 (0.36) | USP1PTGS2AKR1C3AKR1C2PTGS1 | |
| SCHEMBL25298175 | 0.85 | USP1 (0.37) | USP1WDR48PTGS2AKR1C3AKR1C2 | |
| SCHEMBL30320363 | 0.84 | PTGS2 (0.38) | USP1WDR48PTGS2AKR1C3AKR1C2 | |
| SCHEMBL25792085 | 0.84 | PTGS2 (0.38) | USP1WDR48PTGS2AKR1C3AKR1C2 | |
| SCHEMBL25253047 | 0.84 | USP1 (0.37) | USP1PTGS2AKR1C3AKR1C2PTGS1 | |
| SCHEMBL25254428 | 0.81 | USP1 (0.44) | USP1WDR48PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161494-A1 | NITROGEN-CONTAINING FUSED BICYCLIC COMPOUNDS AND THEIR USE AS UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 1 (USP1) INHIBITORS | KSQ Therapeutics, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |