Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 17/20 | 0.55 |
| ▸ | EGFR | P00533 | 15/20 | 0.55 |
| ▸ | ABL1 | P00519 | 15/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.48 |
| ▸ | HCK | P08631 | 14/20 | 0.48 |
| ▸ | KDR | P35968 | 14/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.48 |
| ▸ | MTOR | P42345 | 14/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.48 |
| ▸ | PRKDC | P78527 | 14/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 13/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 8/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23997145 | 1.00 | SRC (0.55) | SRCEGFRABL1PIK3CDHCK | |
| SCHEMBL27604499 | 0.82 | SRC (0.50) | SRCEGFRABL1PIK3CDHCK | |
| SCHEMBL30320603 | 0.79 | PIK3CD (0.65) | SRCEGFRABL1PIK3CDHCK | |
| SCHEMBL21436578 | 0.79 | PIK3CD (0.65) | SRCEGFRABL1PIK3CDHCK | |
| SCHEMBL5801898 | 0.77 | SRC (0.54) | SRCEGFRABL1PIK3CDHCK | |
| SCHEMBL23966926 | 0.77 | RIPK2 (0.56) | SRCEGFRABL1KDRRIPK2 | |
| SCHEMBL30180934 | 0.77 | RIPK2 (0.56) | SRCEGFRABL1KDRRIPK2 | |
| SCHEMBL24096509 | 0.76 | SRC (0.79) | SRCEGFRABL1PIK3CDHCK | |
| SCHEMBL30320468 | 0.76 | SRC (0.79) | SRCEGFRABL1PIK3CDHCK | |
| SCHEMBL23997251 | 0.76 | CYP1A2 (0.69) | SRCEGFRABL1PIK3CDHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116075513-A | Inhibitors of NEK7 kinase | 哈利亚治疗公司 | 2023-05-05 | — | — | CN | disclosed |
| EP-4161933-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |