Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 18/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 18/20 | 0.65 |
| ▸ | PRKDC | P78527 | 18/20 | 0.65 |
| ▸ | ABL1 | P00519 | 16/20 | 0.65 |
| ▸ | EGFR | P00533 | 16/20 | 0.65 |
| ▸ | HCK | P08631 | 16/20 | 0.65 |
| ▸ | SRC | P12931 | 16/20 | 0.65 |
| ▸ | MTOR | P42345 | 16/20 | 0.65 |
| ▸ | EPHB4 | P54760 | 16/20 | 0.65 |
| ▸ | KDR | P35968 | 15/20 | 0.65 |
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.64 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.57 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.57 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21436578 | 1.00 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL130595 | 0.88 | PIK3CD (0.73) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL13201532 | 0.88 | PIK3CD (0.70) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL130418 | 0.87 | PIK3CD (0.73) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL23997199 | 0.85 | SRC (0.73) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL218160 | 0.85 | SRC (0.75) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL130466 | 0.85 | PIK3CD (0.76) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL21436859 | 0.84 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL23917212 | 0.84 | PIK3CD (0.79) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL30320627 | 0.84 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112236429-B | Heteroaryl compounds useful as type II IRAK inhibitors and uses thereof | 默克专利有限公司 | 2024-10-11 | — | — | CN | disclosed |
| CN-116075513-A | Inhibitors of NEK7 kinase | 哈利亚治疗公司 | 2023-05-05 | — | — | CN | disclosed |
| EP-4161933-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |