Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 16/20 | 0.73 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.73 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.73 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.73 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.73 |
| ▸ | PRKDC | P78527 | 14/20 | 0.73 |
| ▸ | ABL1 | P00519 | 13/20 | 0.73 |
| ▸ | EGFR | P00533 | 12/20 | 0.73 |
| ▸ | HCK | P08631 | 12/20 | 0.73 |
| ▸ | MTOR | P42345 | 12/20 | 0.73 |
| ▸ | EPHB4 | P54760 | 12/20 | 0.73 |
| ▸ | KDR | P35968 | 11/20 | 0.73 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.73 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.58 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL130513 | 0.90 | SRC (0.79) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13201532 | 0.89 | PIK3CD (0.70) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21436578 | 0.85 | PIK3CD (0.65) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30320627 | 0.85 | PIK3CD (0.65) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21436859 | 0.85 | PIK3CD (0.65) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL23917212 | 0.85 | PIK3CD (0.79) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30320603 | 0.85 | PIK3CD (0.65) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL130595 | 0.84 | PIK3CD (0.73) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL23917200 | 0.84 | PIK3CD (1.00) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13826003 | 0.83 | SRC (0.68) | SRCPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021226547-A2 | TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME | Halia Therapeutics, Inc. (US) | 2021-11-11 | — | — | WO | disclosed |