Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGMN | Q99538 | 3/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | AGXT | P21549 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL114416 | 1.00 | LGMN (0.53) | LGMNCDK1CDK2NPC1TP53 | |
| Hydrochloric Acid SCHEMBL4301140 | 0.98 | LGMN (0.51) | LGMNCDK1CDK2NPC1TP53 | |
| SCHEMBL1097561 | 0.83 | CHKA (0.52) | NPC1TP53MAPTALOX15RAB9A | |
| SCHEMBL16212228 | 0.83 | HRH4 (0.47) | NPC1TP53MAPTALOX15RAB9A | |
| SCHEMBL5847761 | 0.81 | HRH4 (0.54) | NPC1TP53MAPTALOX15RAB9A | |
| SCHEMBL6262576 | 0.81 | HRH4 (0.54) | NPC1TP53MAPTALOX15RAB9A | |
| SCHEMBL27936855 | 0.80 | LRRK2 (0.59) | LGMNCDK1CDK2SMN1; SMN2LMNA | |
| SCHEMBL10767289 | 0.79 | HRH4 (0.39) | CDK1CDK2MAPTSMN1; SMN2LMNA | |
| SCHEMBL7015551 | 0.79 | LGMN (0.53) | LGMNCDK1CDK2NPC1MAPT | |
| SCHEMBL5848445 | 0.79 | LGMN (0.54) | LGMNCDK2MAPTALOX15CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116789643-B | 2-Aminopyrimidine compound and preparation method and application thereof | 海南医学院 | 2025-05-06 | — | — | CN | claimed |
| CN-116789643-B | 2-Aminopyrimidine compound and preparation method and application thereof | 海南医学院 | 2025-05-06 | — | — | CN | disclosed |
| EP-4153576-A1 | NOTCH INHIBITORS AND USES THEREOF | StemSynergy Therapeutics, Inc. (US) | 2023-03-29 | — | — | EP | disclosed |