Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 12/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20524569 | 1.00 | GRM4 (0.54) | GRM4KDRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22712288 | 0.85 | GRM4 (0.52) | GRM4KDRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30323180 | 0.85 | GRM4 (0.52) | GRM4KDRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4898390 | 0.78 | TRPV1 (0.52) | GRM4NPC1RAB9ATRPV1MAPT | |
| SCHEMBL30006626 | 0.78 | MAPT (0.53) | NPC1RAB9ASMN1; SMN2KDM4ETRPV1 | |
| SCHEMBL30904872 | 0.77 | KDR (0.84) | GRM4KDRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19662769 | 0.77 | KMT2A (0.61) | NPC1RAB9ATP53 | |
| SCHEMBL4032270 | 0.76 | KIT (0.53) | KDR | |
| SCHEMBL3878184 | 0.76 | KIT (0.62) | KDR | |
| SCHEMBL20769948 | 0.76 | KDM4E (0.54) | NPC1RAB9ASMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110520127-B | Piperidinyl-substituted and piperazinyl-substituted heteroaromatic carboxamides as modulators of GPR6 | 武田药品工业株式会社 | 2023-05-16 | — | — | CN | disclosed |