Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.53 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.53 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.53 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.53 |
| ▸ | CBFB | Q13951 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4898390 | 0.88 | TRPV1 (0.52) | MAPTNPC1RAB9ATRPV1BRD4 | |
| SCHEMBL20769948 | 0.85 | KDM4E (0.54) | MAPTNPC1RAB9AKDM4EMEN1 | |
| SCHEMBL31039603 | 0.85 | KDM4E (0.54) | MAPTNPC1RAB9AKDM4EMEN1 | |
| SCHEMBL28490404 | 0.81 | ALDH1A1 (0.50) | MAPTNPC1RAB9AHSD17B10TRPV1 | |
| SCHEMBL29522898 | 0.81 | ALDH1A1 (0.50) | MAPTNPC1RAB9AHSD17B10TRPV1 | |
| SCHEMBL31039610 | 0.80 | RAB9A (0.54) | MAPTNPC1RAB9AKDM4EMEN1 | |
| SCHEMBL20769916 | 0.80 | RAB9A (0.54) | MAPTNPC1RAB9AKDM4EMEN1 | |
| SCHEMBL28998317 | 0.80 | ACSS2 (0.49) | MAPTNPC1RAB9ATRPV1BRD4 | |
| SCHEMBL31510405 | 0.79 | HPGD (0.50) | MAPTNPC1RAB9AKMT2AGLA | |
| SCHEMBL20239415 | 0.79 | CDK8 (0.58) | MAPTNPC1RAB9ATRPV1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337642-A1 | ETHACRYNIC ACID DERIVATIVES AS INHIBITORS OF MPRO PROTEASE AND SARS-COV-2 REPLICATION | Universite Euro-Mediterraneenne de Fes (MA) | 2024-03-20 | — | — | EP | claimed |
| WO-2022240277-A1 | ETHACRYNIC ACID DERIVATIVES AS INHIBITORS OF MPRO PROTEASE AND SARS-COV-2 REPLICATION | UNIVERSITE EURO-MEDITERRANEENNE DE FES (MA) | 2022-11-17 | — | — | WO | claimed |