Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | KCNK3 | O14649 | 6/20 | 0.58 |
| ▸ | KCNK9 | Q9NPC2 | 5/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 3/20 | 0.55 |
| ▸ | MAOA | P21397 | 2/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NT5E | P21589 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19662760 | 0.90 | NPC1 (0.64) | KMT2ANPC1RAB9AMEN1L3MBTL1 | |
| SCHEMBL19662795 | 0.87 | MAOB (0.54) | KMT2ANPC1RAB9AMEN1L3MBTL1 | |
| SCHEMBL21237216 | 0.85 | HDAC8 (0.55) | NPC1RAB9AKCNK3KCNK9MAOB | |
| SCHEMBL4898390 | 0.80 | TRPV1 (0.52) | NPC1RAB9AMAOBMAOAACHE | |
| SCHEMBL30006626 | 0.77 | MAPT (0.53) | KMT2ANPC1RAB9AMEN1MAOB | |
| SCHEMBL29510910 | 0.77 | NPC1 (0.78) | KMT2ANPC1RAB9AMEN1KCNK3 | |
| SCHEMBL30323212 | 0.77 | GRM4 (0.54) | NPC1RAB9ATP53 | |
| SCHEMBL20524569 | 0.77 | GRM4 (0.54) | NPC1RAB9ATP53 | |
| SCHEMBL25591508 | 0.76 | KDR (0.49) | KMT2ANPC1RAB9AMEN1L3MBTL1 | |
| SCHEMBL1168044 | 0.76 | ELANE (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464286-B1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH INC (US) | 2021-08-18 | — | — | EP | disclosed |
| WO-2017205538-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |