Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.57 |
| ▸ | SCD | O00767 | 3/20 | 0.52 |
| ▸ | AR | P10275 | 2/20 | 0.44 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TAS2R8 | Q9NYW2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24123062 | 1.00 | HDAC3 (0.57) | HDAC3HDAC8NCOR2SCDAR | |
| SCHEMBL29483796 | 0.83 | HDAC3 (0.55) | HDAC3HDAC8NCOR2SCDAR | |
| SCHEMBL30326087 | 0.78 | HDAC3 (0.45) | HDAC3HDAC8NCOR2SCDAR | |
| SCHEMBL31412502 | 0.78 | HDAC3 (0.45) | HDAC3HDAC8NCOR2SCDAR | |
| SCHEMBL31319580 | 0.74 | AR (0.56) | HDAC3HDAC8NCOR2SCDAR | |
| SCHEMBL31319588 | 0.74 | AR (0.56) | HDAC3HDAC8NCOR2SCDAR | |
| SCHEMBL1279054 | 0.74 | TAS2R8 (0.65) | TAS2R8 | |
| SCHEMBL22727981 | 0.73 | HDAC3 (0.52) | HDAC3HDAC8NCOR2SCDAR | |
| SCHEMBL31644307 | 0.73 | HDAC3 (0.52) | HDAC3HDAC8NCOR2SCDAR | |
| SCHEMBL28988125 | 0.73 | HDAC3 (0.52) | HDAC3HDAC8NCOR2SCDAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12459927-B2 | Plasma kallikrein inhibitors | MERCK SHARP & DOHME LLC (US) | 2025-11-04 | — | — | US | disclosed |
| US-20230286958-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-09-14 | — | — | US | disclosed |
| EP-4164634-A1 | PLASMA KALLIKREIN INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-04-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230286958-A1 | PLASMA KALLIKREIN INHIBITORS | KLKB1, SERPINE1, KLK5 | HDAC3 2680/4885HDAC8 1818/4885NCOR2 3111/4885 |
| US-12459927-B2 | Plasma kallikrein inhibitors | KLKB1, SERPINE1, KLK5 | HDAC3 2680/4885HDAC8 1818/4885NCOR2 3111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.