Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 10/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30330180 | 0.91 | MAPT (0.37) | PARP1MAPTALDH1A1PKMCYP1A2 | |
| SCHEMBL28022683 | 0.86 | PARP1 (0.41) | PARP1MAPTALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL30329872 | 0.82 | CYP1A2 (0.50) | PARP1MAPTALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL30329748 | 0.82 | GPR35 (0.37) | PARP1MAPTALDH1A1CYP1A2MAPK1 | |
| SCHEMBL30329662 | 0.80 | MAPT (0.49) | MAPTALDH1A1PKMCYP1A2SMN1; SMN2 | |
| SCHEMBL29284840 | 0.77 | PARP1 (0.39) | PARP1MAPTALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL29739713 | 0.76 | PARP1 (0.51) | PARP1MAPTALDH1A1CYP1A2MEN1 | |
| SCHEMBL6634968 | 0.76 | PARP1 (0.51) | PARP1MAPTALDH1A1CYP1A2MEN1 | |
| SCHEMBL30330528 | 0.74 | TXNRD1 (0.50) | MAPTALDH1A1CYP1A2MEN1POLB | |
| SCHEMBL30330341 | 0.74 | GPR35 (0.35) | MAPTALDH1A1CYP1A2MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118647610-A | Novel modulators of EHMT1 and EHMT2 and therapeutic uses thereof | 探戈医药股份有限公司 | 2024-09-13 | — | — | CN | disclosed |
| EP-4416143-A1 | NOVEL MODULATORS OF EHMT1 AND EHMT2 AND THERAPEUTIC USE THEREOF | Tango Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023064586-A1 | NOVEL MODULATORS OF EHMT1 AND EHMT2 AND THERAPEUTIC USE THEREOF | TANGO THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |