Sugi Predict

Sugi Predict / Compounds / SCHEMBL3033258

SCHEMBL3033258

SCHEMBL3033258

CCOC(=O)c1cn2c(N)cccc2n1

nearest known ligand 0.75

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 1/20 0.75
▸ CYP1A2 P05177 2/20 0.54
▸ MAPK1 P28482 1/20 0.52
▸ KDM4E B2RXH2 6/20 0.51
▸ POLB P06746 1/20 0.51
▸ RAB9A P51151 4/20 0.47
▸ NPC1 O15118 3/20 0.47
▸ GABRA2 P47869 3/20 0.47
▸ GABRB2 P47870 3/20 0.47
▸ RXFP1 Q9HBX9 1/20 0.45
▸ CYP2C9 P11712 1/20 0.45
▸ CYP2C19 P33261 1/20 0.45
▸ SMN1; SMN2 Q16637 1/20 0.45
▸ ALDH1A1 P00352 1/20 0.45
▸ HPGD P15428 1/20 0.45
▸ MAPT P10636 1/20 0.45
▸ KMT2A Q03164 1/20 0.44
▸ ADORA2A P29274 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL118187 0.86 GAA (0.75) GAACYP1A2MAPK1KDM4EPOLB
SCHEMBL101291 0.86 GAA (1.00) GAACYP1A2MAPK1KDM4EPOLB
SCHEMBL102137 0.83 GAA (0.75) GAACYP1A2MAPK1KDM4EPOLB
SCHEMBL7274660 0.83 GAA (0.75) GAACYP1A2MAPK1KDM4EPOLB
SCHEMBL12119842 0.83 GAA (0.75) GAACYP1A2MAPK1KDM4EPOLB
SCHEMBL23530875 0.83 GAA (0.75) GAACYP1A2MAPK1KDM4EPOLB
SCHEMBL25262974 0.82 GAA (0.73) GAACYP1A2MAPK1KDM4EPOLB
SCHEMBL118407 0.82 GAA (0.73) GAACYP1A2MAPK1KDM4EPOLB
SCHEMBL8608783 0.81 GAA (0.71) GAACYP1A2MAPK1KDM4EPOLB
SCHEMBL8610256 0.81 GAA (0.71) GAACYP1A2MAPK1KDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120006268-A Leadless high-phosphorus chemical nickel plating solution 珠海联鼎化工设备有限公司 2025-05-16 — — CN claimed
US-12441724-B2 Inhibitors of plasma kallikrein and uses thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2025-10-14 — — US disclosed
CN-120006268-A Leadless high-phosphorus chemical nickel plating solution 珠海联鼎化工设备有限公司 2025-05-16 — — CN disclosed
CN-118063491-A Imide catalyst auxiliary agent, polyimide film and preparation method 中国科学院化学研究所 2024-05-24 — — CN disclosed
US-20230078513-A1 INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF SHIRE HUMAN GENETIC THERAPIES, INC. 2023-03-16 — — US disclosed
CN-109652166-B Volatile cleaning-free stretching oil and preparation method thereof 东莞市登喜达表面处理科技有限公司 2023-01-06 — — CN disclosed
CN-110770233-B Fused bicyclic compound and application thereof in medicine 广东东阳光药业有限公司 2022-07-26 — — CN disclosed
US-11352356-B2 Inhibitors of plasma kallikrein and uses thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2022-06-07 — — US disclosed
EP-3765459-A1 SUBSTITUTED IMIDAZOPYRIDINES AS INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF Shire Human Genetic Therapies, Inc. (US) 2021-01-20 — — EP disclosed
US-20200317667-A1 INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF SHIRE HUMAN GENETIC THERAPIES, INC. 2020-10-08 — — US disclosed
US-20130172549-A1 Heteroaryl amide derivatives H. LUNDBECK A/S (DK) 2013-07-04 — — US disclosed
EP-2591675-A1 Heteroaryl amide derivatives H. Lundbeck A/S (DK) 2013-05-15 — — EP disclosed
EP-2591675-A1 Heteroaryl amide derivatives H. Lundbeck A/S (DK) 2013-05-15 — — EP disclosed
US-8431593-B2 Heteroaryl amide derivatives H. LUNDBECK A/S (DK) 2013-04-30 — — US disclosed
US-8431593-B2 Heteroaryl amide derivatives H. LUNDBECK A/S (DK) 2013-04-30 — — US disclosed
US-20100216763-A1 Heteroaryl Amide Derivatives H. LUNDBECK A/S (DK) 2010-08-26 — — US disclosed
US-20100216763-A1 Heteroaryl Amide Derivatives H. LUNDBECK A/S (DK) 2010-08-26 — — US disclosed
EP-2096923-A2 HETEROARYL AMIDE DERIVATIVES H. Lundbeck A/S (DK) 2009-09-09 — — EP disclosed
WO-2008066789-A2 HETEROARYL AMIDE DERIVATIVES H. LUNDBECK A/S (DK) 2008-06-05 — — WO disclosed
WO-2008066789-A2 HETEROARYL AMIDE DERIVATIVES H. LUNDBECK A/S (DK) 2008-06-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11352356-B2 Inhibitors of plasma kallikrein and uses thereof KLKB1, KLK1, KLK5 GAA 1581/4885CYP1A2 2984/4885MAPK1 2173/4885
US-12441724-B2 Inhibitors of plasma kallikrein and uses thereof KLKB1, KLK1, KLK5 GAA 1581/4885CYP1A2 2984/4885MAPK1 2173/4885
US-20200317667-A1 INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF KLKB1, KLK1, KLK5 GAA 1581/4885CYP1A2 2984/4885MAPK1 2173/4885
US-20100216763-A1 Heteroaryl Amide Derivatives HCAR2, PIGS, GPR52 GAA 1377/4885CYP1A2 398/4885MAPK1 3641/4885
US-20230078513-A1 INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF KLKB1, KLK1, KLK5 GAA 1581/4885CYP1A2 2984/4885MAPK1 2173/4885
US-20130172549-A1 Heteroaryl amide derivatives HCAR2, PIGS, GPR52 GAA 1377/4885CYP1A2 398/4885MAPK1 3641/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.