Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 10/20 | 0.42 |
| ▸ | CNR2 | P34972 | 9/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL302783 | 0.88 | SIRT2 (0.45) | NR1H2SIRT2MEN1KMT2ACNR1 | |
| SCHEMBL3380912 | 0.87 | SIRT2 (0.45) | NR1H2SIRT2MEN1KMT2ACNR1 | |
| SCHEMBL303335 | 0.87 | NR1H2 (0.45) | NR1H2SIRT2MEN1KMT2ACNR1 | |
| SCHEMBL303675 | 0.85 | SIRT2 (0.43) | NR1H2SIRT2MEN1KMT2ACNR1 | |
| SCHEMBL3376406 | 0.85 | SIRT2 (0.44) | NR1H2SIRT2MEN1KMT2ACNR1 | |
| SCHEMBL3377129 | 0.84 | MEN1 (0.55) | NR1H2SIRT2MEN1KMT2ACNR1 | |
| SCHEMBL303674 | 0.84 | SIRT2 (0.44) | NR1H2SIRT2MEN1KMT2ACNR1 | |
| SCHEMBL2186792 | 0.84 | SIRT2 (0.45) | NR1H2SIRT2MEN1KMT2ACNR1 | |
| SCHEMBL3380436 | 0.82 | NR1H2 (0.45) | NR1H2MEN1KMT2ARORC | |
| SCHEMBL3379276 | 0.81 | NR1H2 (0.45) | NR1H2SIRT2MEN1KMT2ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |