Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL302783 | 0.94 | SIRT2 (0.45) | SIRT2MEN1KMT2ARORCKCNA5 | |
| SCHEMBL3380912 | 0.89 | SIRT2 (0.45) | SIRT2MEN1KMT2ARORCKCNA5 | |
| SCHEMBL303336 | 0.85 | NR1H2 (0.45) | SIRT2MEN1KMT2ARORCKCNA5 | |
| SCHEMBL3376406 | 0.85 | SIRT2 (0.44) | SIRT2MEN1KMT2ARORCKCNA5 | |
| SCHEMBL3377129 | 0.84 | MEN1 (0.55) | SIRT2MEN1KMT2ARORCKCNA5 | |
| SCHEMBL303335 | 0.84 | NR1H2 (0.45) | SIRT2MEN1KMT2ARORCKCNA5 | |
| SCHEMBL2186792 | 0.84 | SIRT2 (0.45) | SIRT2MEN1KMT2ARORCKCNA5 | |
| SCHEMBL303674 | 0.83 | SIRT2 (0.44) | SIRT2MEN1KMT2ARORCKCNA5 | |
| SCHEMBL3379276 | 0.79 | NR1H2 (0.45) | SIRT2MEN1KMT2ARORCKCNA5 | |
| SCHEMBL3377427 | 0.78 | KCNA5 (0.45) | SIRT2MEN1KMT2ARORCKCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |