Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23883871 | 1.00 | KDM1A (0.49) | KDM1AFFAR1FFAR4RAB9ASMN1; SMN2 | |
| SCHEMBL4540283 | 0.87 | KDM1A (0.56) | KDM1AFFAR1FFAR4SMN1; SMN2MAOB | |
| SCHEMBL23899537 | 0.84 | KDM1A (0.50) | KDM1AFFAR1FFAR4RAB9ASMN1; SMN2 | |
| SCHEMBL23884036 | 0.84 | KDM1A (0.47) | KDM1AFFAR1FFAR4RAB9ASMN1; SMN2 | |
| SCHEMBL30234836 | 0.84 | KDM1A (0.47) | KDM1AFFAR1FFAR4RAB9ASMN1; SMN2 | |
| SCHEMBL26133457 | 0.81 | MRGPRX4 (0.48) | KDM1AFFAR1FFAR4MAOBL3MBTL1 | |
| SCHEMBL2113202 | 0.81 | PKM (0.57) | FFAR1FFAR4RAB9ASMN1; SMN2MAOB | |
| SCHEMBL30660563 | 0.81 | FFAR1 (0.65) | KDM1AFFAR1FFAR4RAB9ASMN1; SMN2 | |
| SCHEMBL2577580 | 0.81 | FFAR1 (0.65) | KDM1AFFAR1FFAR4RAB9ASMN1; SMN2 | |
| SCHEMBL8252175 | 0.81 | THRB (0.58) | KDM1ASMN1; SMN2MAOBMAPTTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916748-A | Indole derivatives as alpha-1 antitrypsin modulators for the treatment of alpha-1 antitrypsin deficiency (AATD) | 弗特克斯药品有限公司 | 2023-04-04 | — | — | CN | disclosed |