Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 6/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | DAO | P14920 | 1/20 | 0.51 |
| ▸ | CBX7 | O95931 | 1/20 | 0.47 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.47 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.47 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23997457 | 1.00 | PGR (0.62) | PGRLMNAHTTDAOCBX7 | |
| SCHEMBL23997393 | 0.84 | KMT2A (0.54) | PGRLMNAHTTDAOBRD4 | |
| SCHEMBL30345080 | 0.84 | KMT2A (0.54) | PGRLMNAHTTDAOBRD4 | |
| SCHEMBL23997338 | 0.84 | PGR (0.51) | PGRLMNAHTTDAOBRD4 | |
| SCHEMBL30336900 | 0.84 | PGR (0.51) | PGRLMNAHTTDAOBRD4 | |
| SCHEMBL22465733 | 0.82 | LMNA (0.57) | PGRLMNAHTTDAOCBX7 | |
| SCHEMBL25720013 | 0.81 | PGR (0.48) | PGRLMNAHTTBRD4OPRM1 | |
| SCHEMBL23997482 | 0.81 | LMNA (0.75) | PGRLMNAHTTDAOIDO1 | |
| SCHEMBL30345072 | 0.81 | LMNA (0.75) | PGRLMNAHTTDAOIDO1 | |
| SCHEMBL20715684 | 0.80 | LMNA (0.65) | PGRLMNAHTTDAOBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115836054-B | IL4I1 inhibitors and methods of use | 默沙东有限责任公司 | 2024-12-10 | — | — | CN | disclosed |
| CN-115836054-A | IL4I1 inhibitors and methods of use | 默沙东有限责任公司 | 2023-03-21 | — | — | CN | disclosed |
| EP-4146644-A1 | IL4I1 INHIBITORS AND METHODS OF USE | Merck Sharp & Dohme LLC (US) | 2023-03-15 | — | — | EP | disclosed |