Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 2/20 | 0.40 |
| ▸ | SKP1 | P63208 | 2/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25407146 | 1.00 | GPR119 (0.45) | GPR119CYP11B2MAP4K4KIF18ACYP3A4 | |
| SCHEMBL30480339 | 0.90 | MAP4K4 (0.52) | GPR119MAP4K4TSHRRETCKS1B | |
| SCHEMBL25248226 | 0.90 | MAP4K4 (0.52) | GPR119MAP4K4TSHRRETCKS1B | |
| SCHEMBL30456054 | 0.83 | USP2 (0.39) | CYP3A4CYP2C19TSHRHSD17B10CYP2D6 | |
| SCHEMBL25275503 | 0.83 | GPR119 (0.44) | GPR119MAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL30455853 | 0.83 | GPR119 (0.44) | GPR119MAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL1780700 | 0.77 | RET (0.51) | GPR119CYP11B2MAP4K4CYP3A4CYP2C19 | |
| SCHEMBL29455974 | 0.77 | RET (0.51) | GPR119CYP11B2MAP4K4CYP3A4CYP2C19 | |
| SCHEMBL30328017 | 0.76 | HRH3 (0.53) | GPR119CYP11B2MAP4K4KIF18ACYP3A4 | |
| SCHEMBL27027530 | 0.75 | MAP4K4 (0.55) | GPR119MAP4K4RETCKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4192588-A1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2023-06-14 | — | — | EP | disclosed |
| CN-115835911-A | Imidazo [1,2-a ] pyridine compounds for the treatment of autoimmune diseases | 豪夫迈·罗氏有限公司 | 2023-03-21 | — | — | CN | disclosed |