Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL9126028 | 0.95 | FFAR3 (0.35) | FFAR3LCKFYNKDM4EL3MBTL1 | |
| SCHEMBL8665225 | 0.82 | FFAR3 (0.35) | FFAR3KDM4EL3MBTL1ALDH1A1TDP1 | |
| SCHEMBL28142666 | 0.82 | KDM4E (0.31) | KDM4EL3MBTL1 | |
| SCHEMBL1792330 | 0.82 | — | — | |
| SCHEMBL21255198 | 0.70 | — | — | |
| SCHEMBL1803265 | 0.70 | — | — | |
| SCHEMBL11599646 | 0.70 | — | — | |
| Acetic Acid SCHEMBL19356582 | 0.69 | FFAR3 (0.50) | FFAR3LCKFYNKDM4EALDH1A1 | |
| N,N-Dimethylethanaminium SCHEMBL3408050 | 0.69 | — | — | |
| Diethylamine SCHEMBL21834232 | 0.69 | TP53 (0.57) | FFAR3LCKFYNKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106918651-B | Method for detecting related substances of posaconazole | 江苏先声药业有限公司 | 2021-06-04 | — | — | CN | claimed |
| CN-106918651-A | A kind of relevant substance detecting method of posaconazole | 江苏先声药业有限公司 | 2017-07-04 | — | — | CN | claimed |
| US-11332779-B2 | Nucleic acid melting analysis with saturation dyes | BIOFIRE DEFENSE, LLC (US) | 2022-05-17 | — | — | US | disclosed |
| CN-106918651-B | Method for detecting related substances of posaconazole | 江苏先声药业有限公司 | 2021-06-04 | — | — | CN | disclosed |
| US-20200248247-A1 | Nucleic Acid Melting Analysis with Saturation Dyes | UNIVERSITY OF UTAH | 2020-08-06 | — | — | US | disclosed |
| EP-2826867-B1 | Nucleic acid melting analysis with saturation dyes | UNIV UTAH RES FOUND (US) | 2020-06-03 | — | — | EP | disclosed |
| US-10655169-B2 | Nucleic acid melting analysis with saturation dyes | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2020-05-19 | — | — | US | disclosed |
| EP-2772552-B1 | Amplicon melting analysis with saturation dyes | UNIV UTAH RES FOUND (US) | 2018-10-10 | — | — | EP | disclosed |
| US-20180066137-A1 | AMPLICON MELTING ANALYSIS WITH SATURATION DYES | WITTWER CARL T (US) | 2018-03-08 | — | — | US | disclosed |
| US-9850381-B2 | Amplicon melting analysis with saturation dyes | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2017-12-26 | — | — | US | disclosed |
| US-20170226573-A1 | NUCLEIC ACID MELTING ANALYSIS WITH SATURATION DYES | UNIVERSITY OF UTAH | 2017-08-10 | — | — | US | disclosed |
| CN-101198706-A | Nucleic acid melting analysis with saturating dyes | UNIV UTAH RES FOUND (US) | 2008-06-11 | — | — | CN | disclosed |
| EP-1774047-A2 | NUCLEIC ACID MELTING ANALYSIS WITH SATURATION DYES | University of Utah Research Foundation (US) | 2007-04-18 | — | — | EP | disclosed |
| CN-1934270-A | Amplicon melting analysis with saturation dyes | UNIV UTAH RES FOUND (US) | 2007-03-21 | — | — | CN | disclosed |
| US-20070020672-A1 | Nucleic acid melting analysis with saturation dyes | IDAHO TECHNOLOGY, INC. (US) | 2007-01-25 | — | — | US | disclosed |
| WO-2006121423-A2 | NUCLEIC ACID MELTING ANALYSIS WITH SATURATION DYES | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2006-11-16 | — | — | WO | disclosed |
| US-20060019253-A1 | Polymerase chain reaction analysis by mixing a dsDNA binding dye with a sample of target nucleic acid and primers configured for amplifying; melting the amplified target nucleic acid to generate a melting curve; plotting; repeating; comparison; melting curve difference for each target nucleic acid | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-01-26 | — | — | US | disclosed |
| US-20050233335-A1 | standard PCR solution with additional saturating double-stranded (ds) DNA binding dye; fluorescence; cyanine dyes | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2005-10-20 | — | — | US | disclosed |
| EP-1558762-A2 | AMPLICON MELTING ANALYSIS WITH SATURATION DYES | University of Utah Research Foundation (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004038038-A2 | AMPLICON MELTING ANALYSIS WITH SATURATION DYES | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019253-A1 | Polymerase chain reaction analysis by mixing a dsDNA binding dye with a sample of target nucleic acid and primers configured for amplifying; melting the amplified target nucleic acid to generate a melting curve; plotting; repeating; comparison; melting curve difference for each target nucleic acid | POLL, DNA2, POLRMT | FFAR3 4149/4885LCK 3843/4885FYN 4698/4885 |
| US-20070020672-A1 | Nucleic acid melting analysis with saturation dyes | DNA2, POLL, POLRMT | FFAR3 1955/4885LCK 4447/4885FYN 4772/4885 |
| US-20050233335-A1 | standard PCR solution with additional saturating double-stranded (ds) DNA binding dye; fluorescence; cyanine dyes | DDB1, POLL, POLRMT | FFAR3 1521/4885LCK 3727/4885FYN 4242/4885 |
| US-20180066137-A1 | AMPLICON MELTING ANALYSIS WITH SATURATION DYES | NOP2, POLL, DNA2 | FFAR3 2135/4885LCK 3417/4885FYN 4064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.