Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 9/20 | 0.47 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | CAMK1D | Q8IU85 | 3/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.30 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25817008 | 1.00 | RIPK1 (0.47) | RIPK1EIF2AK4HCRTR1HCRTR2CAMK1D | |
| SCHEMBL25257155 | 0.92 | RIPK1 (0.51) | RIPK1EIF2AK4JAK2NTRK1 | |
| SCHEMBL30338877 | 0.92 | RIPK1 (0.51) | RIPK1EIF2AK4JAK2NTRK1 | |
| SCHEMBL30338792 | 0.88 | RIPK1 (0.53) | RIPK1 | |
| SCHEMBL25303686 | 0.88 | RIPK1 (0.53) | RIPK1 | |
| SCHEMBL30338542 | 0.86 | RIPK1 (0.42) | RIPK1TMPRSS15 | |
| SCHEMBL25299996 | 0.86 | RIPK1 (0.42) | RIPK1TMPRSS15 | |
| SCHEMBL25816842 | 0.84 | RIPK1 (0.44) | RIPK1KDM4E | |
| SCHEMBL25255972 | 0.83 | RIPK1 (0.50) | RIPK1EIF2AK4JAK2NTRK1 | |
| SCHEMBL30338522 | 0.83 | RIPK1 (0.50) | RIPK1EIF2AK4JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |
| EP-4157835-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-04-05 | — | — | EP | disclosed |