Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27191792 | 0.83 | HTT (0.42) | HTTATMNR1H2USP2SMN1; SMN2 | |
| SCHEMBL17925598 | 0.82 | HTT (0.41) | HTTATMNR1H2USP2SMN1; SMN2 | |
| SCHEMBL30752622 | 0.80 | ADORA1 (0.39) | HTTATMADORA1NR1H2USP2 | |
| SCHEMBL27192159 | 0.79 | FAAH (0.43) | HTTATMNR1H2USP2SMN1; SMN2 | |
| SCHEMBL22615344 | 0.76 | MEN1 (0.46) | ADORA1NR1H2USP2SMN1; SMN2ESR2 | |
| SCHEMBL22102675 | 0.75 | FAAH (0.35) | HTTATMADORA1USP2SMN1; SMN2 | |
| SCHEMBL25335672 | 0.75 | MEN1 (0.45) | HTTATMNR1H2USP2SMN1; SMN2 | |
| SCHEMBL30793645 | 0.75 | MEN1 (0.40) | HTTATMADORA1NR1H2USP2 | |
| SCHEMBL30793659 | 0.75 | MEN1 (0.40) | HTTATMADORA1NR1H2USP2 | |
| SCHEMBL22615432 | 0.75 | ADORA1 (0.42) | HTTATMADORA1NR1H2ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157888-A1 | MODIFIED PROTEINS AND PROTEIN DEGRADERS | Cullgen (Shanghai), Inc. (CN) | 2023-04-05 | — | — | EP | disclosed |