Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 3/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | CTSC | P53634 | 2/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | NPM1 | P06748 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30340490 | 0.89 | MAPK10 (0.52) | EGFRMAPK10BRD4JAK2JAK3 | |
| SCHEMBL30340737 | 0.85 | MAPK10 (0.51) | EGFRMAPK10BRD4PTK2ALK | |
| SCHEMBL30340587 | 0.84 | CDK2 (0.55) | EGFRMAPK10BRD4PTK2ALK | |
| SCHEMBL30340656 | 0.83 | IGF1R (0.53) | EGFRMAPK10BRD4JAK3CTSC | |
| SCHEMBL30340548 | 0.83 | MAPK10 (0.51) | EGFRMAPK10BRD4JAK2JAK3 | |
| SCHEMBL30340667 | 0.82 | MAPK10 (0.55) | EGFRMAPK10JAK3CTSCALK | |
| SCHEMBL30340630 | 0.81 | MAPK10 (0.51) | EGFRMAPK10JAK3CTSCPTK2 | |
| SCHEMBL30340705 | 0.81 | MAPK10 (0.49) | EGFRMAPK10BRD4JAK2JAK3 | |
| SCHEMBL30340493 | 0.79 | IGF1R (0.54) | EGFRMAPK10BRD4PTK2ALK | |
| SCHEMBL30340484 | 0.79 | CDK2 (0.56) | EGFRMAPK10BRD4JAK3ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4402127-A1 | AMINOPYRIDINES AS ACTIVATORS OF PI3 KINASE | UCL Business Ltd (GB) | 2024-07-24 | — | — | EP | disclosed |
| WO-2023041905-A1 | AMINOPYRIDINES AS ACTIVATORS OF PI3 KINASE | UCL BUSINESS LTD (GB) | 2023-03-23 | — | — | WO | disclosed |