Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.53 |
| ▸ | CDK2 | P24941 | 3/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.50 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.47 |
| ▸ | INSR | P06213 | 3/20 | 0.47 |
| ▸ | NPM1 | P06748 | 2/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30340587 | 0.89 | CDK2 (0.55) | IGF1RCDK2DYRK1BMAPK10DYRK3 | |
| SCHEMBL30340493 | 0.84 | IGF1R (0.54) | IGF1RCDK2DYRK1BMAPK10EGFR | |
| SCHEMBL30340548 | 0.84 | MAPK10 (0.51) | IGF1RCDK2DYRK1BMAPK10EGFR | |
| SCHEMBL30340705 | 0.84 | MAPK10 (0.49) | IGF1RCDK2DYRK1BMAPK10DYRK3 | |
| SCHEMBL30340484 | 0.83 | CDK2 (0.56) | IGF1RCDK2DYRK1BMAPK10DYRK3 | |
| SCHEMBL30340490 | 0.83 | MAPK10 (0.52) | IGF1RCDK2DYRK1BMAPK10EGFR | |
| SCHEMBL30340650 | 0.83 | EGFR (0.53) | IGF1RCDK2DYRK1BMAPK10EGFR | |
| SCHEMBL30340630 | 0.83 | MAPK10 (0.51) | IGF1RCDK2DYRK1BMAPK10DYRK3 | |
| SCHEMBL30340504 | 0.82 | MAPK10 (0.51) | IGF1RCDK2DYRK1BMAPK10DYRK3 | |
| SCHEMBL30340921 | 0.80 | IGF1R (0.54) | IGF1RCDK2DYRK1BEGFRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4402127-A1 | AMINOPYRIDINES AS ACTIVATORS OF PI3 KINASE | UCL Business Ltd (GB) | 2024-07-24 | — | — | EP | disclosed |
| WO-2023041905-A1 | AMINOPYRIDINES AS ACTIVATORS OF PI3 KINASE | UCL BUSINESS LTD (GB) | 2023-03-23 | — | — | WO | disclosed |