Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15972630 | 1.00 | MAPT (0.45) | MAPTCYP1A2GAARECQLNOTUM | |
| SCHEMBL17144343 | 0.81 | NOTUM (0.46) | MAPTCYP1A2GAARECQLNOTUM | |
| SCHEMBL30405765 | 0.81 | NOTUM (0.46) | MAPTCYP1A2GAARECQLNOTUM | |
| SCHEMBL31185912 | 0.80 | MAPT (0.46) | MAPTCYP1A2GAARECQLMAPK1 | |
| SCHEMBL31177853 | 0.80 | MAPT (0.46) | MAPTCYP1A2GAARECQLMAPK1 | |
| SCHEMBL31661385 | 0.80 | NOTUM (0.45) | MAPTCYP1A2GAARECQLNOTUM | |
| SCHEMBL18725355 | 0.80 | SMN1; SMN2 (0.46) | MAPTCYP1A2NOTUMMAPK1SMN1; SMN2 | |
| SCHEMBL18367820 | 0.80 | MAPT (0.46) | MAPTCYP1A2GAARECQLMAPK1 | |
| SCHEMBL544568 | 0.80 | MAPT (0.46) | MAPTCYP1A2GAARECQLMAPK1 | |
| SCHEMBL7107317 | 0.79 | CTSA (0.47) | MAPTCYP1A2GAARECQLMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168393-A1 | 2-OXOIMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-04-26 | — | — | EP | disclosed |