Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 10/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3033766 | 0.81 | KDM4E (0.56) | KDM4ENR3C2ESR1ARALDH1A1 | |
| SCHEMBL13236489 | 0.76 | KDM4E (0.51) | KDM4ENR3C2ESR1ARALDH1A1 | |
| SCHEMBL8259771 | 0.64 | NR3C2 (0.67) | KDM4ENR3C2ALDH1A1 | |
| SCHEMBL14273571 | 0.63 | ALDH1A1 (0.61) | KDM4EALDH1A1KMT2AMEN1ESR2 | |
| SCHEMBL4999675 | 0.62 | MET (0.36) | KDM4ENR3C2ARALDH1A1LMNA | |
| SCHEMBL7814851 | 0.61 | ALDH1A1 (0.60) | KDM4EALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL13685506 | 0.61 | KDM4E (0.52) | KDM4ENR3C2ALDH1A1KMT2AMEN1 | |
| SCHEMBL30162537 | 0.60 | KDM4E (0.50) | KDM4ENR3C2ALDH1A1KMT2AMEN1 | |
| SCHEMBL20954628 | 0.60 | KDM4E (0.50) | KDM4ENR3C2ALDH1A1KMT2AMEN1 | |
| SCHEMBL9909094 | 0.59 | KDM4E (0.40) | KDM4EARALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | MULLAN MICHAEL J | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | APP, PSEN1, PSEN2 | KDM4E 4759/4885NR3C2 3147/4885ESR1 2749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.