Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23744101 | 1.00 | NPC1 (0.48) | NPC1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL23744761 | 0.86 | ALDH1A1 (0.48) | NPC1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL23744762 | 0.86 | ALDH1A1 (0.48) | NPC1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL13666122 | 0.84 | ALDH1A1 (0.56) | NPC1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL23744797 | 0.83 | ACVR1 (0.47) | NPC1RAB9AZAP70MCHR1HRH4 | |
| SCHEMBL31142841 | 0.81 | HTR3A (0.56) | NPC1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL10219262 | 0.81 | HTR3A (0.56) | NPC1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL15543531 | 0.81 | HTR3A (0.56) | NPC1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL23744804 | 0.80 | SCN9A (0.42) | MCHR1NCF1HRH4HRH3PRKCQ | |
| SCHEMBL23744103 | 0.80 | MCHR1 (0.42) | NPC1ALDH1A1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230129359-A1 | MUSCARINIC RECEPTOR 4 ANTAGONISTS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. | 2023-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230129359-A1 | MUSCARINIC RECEPTOR 4 ANTAGONISTS AND METHODS OF USE | CHRM4, CHRM2, CHRM5 | NPC1 1236/4885ALDH1A1 1378/4885RAB9A 3190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.