Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 16/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.46 |
| ▸ | ULK1 | O75385 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30406752 | 0.88 | LRRK2 (0.39) | RETMAPK8MAPK9ULK1MAPK10 | |
| SCHEMBL30407002 | 0.83 | ULK1 (0.48) | RETMAPK8MAPK9ULK1MAPK10 | |
| SCHEMBL10165915 | 0.83 | MAPK8 (0.56) | RETMAPK8MAPK9ULK1MAPK10 | |
| SCHEMBL16266502 | 0.79 | MAPK1 (0.53) | RETMAPK8MAPK9ULK1MAPK10 | |
| SCHEMBL6886583 | 0.73 | MKNK1 (0.48) | RETMAPK8MAPK9MKNK1MKNK2 | |
| SCHEMBL28386712 | 0.72 | MAPK8 (0.50) | RETMAPK8MAPK9MKNK1MKNK2 | |
| SCHEMBL22241892 | 0.72 | JAK1 (0.52) | MAPK8MAPK9MAPK10 | |
| SCHEMBL28314223 | 0.70 | KDM4E (0.58) | RETMAPK8MAPK9MKNK1MKNK2 | |
| SCHEMBL28448559 | 0.69 | MAPK8 (0.51) | RETMAPK8MAPK9MKNK1MKNK2 | |
| SCHEMBL11916208 | 0.69 | ULK1 (0.46) | ULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415818-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |