Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 14/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25158118 | 1.00 | TDO2 (0.43) | TDO2BRD4MAP3K11DYRK1ACLK2 | |
| SCHEMBL25199123 | 0.91 | TDO2 (0.42) | TDO2BRD4MAP3K11DYRK1ACLK2 | |
| SCHEMBL30347782 | 0.91 | TDO2 (0.42) | TDO2BRD4MAP3K11DYRK1ACLK2 | |
| SCHEMBL30346621 | 0.90 | TDO2 (0.38) | TDO2BRD4MAP3K11DYRK1ACLK2 | |
| SCHEMBL25211350 | 0.90 | TDO2 (0.38) | TDO2BRD4MAP3K11DYRK1ACLK2 | |
| SCHEMBL25208447 | 0.88 | TDO2 (0.44) | TDO2BRD4DYRK1ACLK2CLK3 | |
| SCHEMBL30348149 | 0.88 | TDO2 (0.44) | TDO2BRD4DYRK1ACLK2CLK3 | |
| SCHEMBL25204091 | 0.88 | TDO2 (0.48) | TDO2DYRK1ACLK2GSK3BMAPK1 | |
| SCHEMBL25197263 | 0.88 | DYRK1A (0.46) | TDO2DYRK1ACLK2CLK3DYRK1B | |
| SCHEMBL30348658 | 0.88 | DYRK1A (0.46) | TDO2DYRK1ACLK2CLK3DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415818-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |