Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 13/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25200736 | 1.00 | LRRK2 (0.49) | LRRK2JAK3ROCK2ROCK1CDC42BPB | |
| SCHEMBL30347892 | 0.89 | LRRK2 (0.46) | LRRK2JAK3ROCK2ROCK1CDC42BPB | |
| SCHEMBL25204231 | 0.89 | LRRK2 (0.46) | LRRK2JAK3ROCK2ROCK1CDC42BPB | |
| SCHEMBL30400624 | 0.85 | ROCK2 (0.52) | LRRK2ROCK2ROCK1CDC42BPBTDO2 | |
| SCHEMBL26174628 | 0.85 | ROCK2 (0.52) | LRRK2ROCK2ROCK1CDC42BPBTDO2 | |
| SCHEMBL25203990 | 0.83 | LRRK2 (0.53) | LRRK2JAK3ROCK2ROCK1CDC42BPB | |
| SCHEMBL25158143 | 0.81 | LRRK2 (0.50) | LRRK2JAK3ROCK2ROCK1CDC42BPB | |
| SCHEMBL30349516 | 0.80 | EGFR (0.50) | LRRK2JAK3ROCK2ROCK1CDC42BPB | |
| SCHEMBL25201354 | 0.80 | EGFR (0.50) | LRRK2JAK3ROCK2ROCK1CDC42BPB | |
| SCHEMBL30400374 | 0.80 | ALK (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415818-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |