Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 5/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | UBE2N | P61088 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26919915 | 1.00 | ALK (0.38) | ALKLMNAALDH1A1GAAHTR6 | |
| SCHEMBL22632905 | 0.90 | ALK (0.40) | ALKLMNAALDH1A1GAAHTR6 | |
| SCHEMBL22632544 | 0.86 | ALK (0.36) | ALKLMNAALDH1A1GAAHTR6 | |
| SCHEMBL22632661 | 0.85 | ALK (0.36) | ALKLMNAALDH1A1GAAHTR6 | |
| SCHEMBL30349522 | 0.84 | HTR6 (0.35) | ALKHTR6CYP19A1PPARG | |
| SCHEMBL31405774 | 0.83 | HTR6 (0.36) | ALKLMNAALDH1A1HTR6KDM1A | |
| SCHEMBL22638215 | 0.83 | ALK (0.34) | ALKLMNAHTR6KDM1ACYP19A1 | |
| SCHEMBL30711130 | 0.82 | CD4 (0.37) | ALKLMNAALDH1A1HTR6CYP19A1 | |
| SCHEMBL30349752 | 0.82 | ALK (0.34) | ALKLMNAGAAHTR6KDM1A | |
| SCHEMBL30349581 | 0.82 | HTR6 (0.31) | ALKHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4178672-A1 | MODULATORS OF THR-ß AND METHODS OF USE THEREOF | Aligos Therapeutics, Inc. (US) | 2023-05-17 | — | — | EP | claimed |
| EP-4178672-A1 | MODULATORS OF THR-ß AND METHODS OF USE THEREOF | Aligos Therapeutics, Inc. (US) | 2023-05-17 | — | — | EP | disclosed |