Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.39 |
| ▸ | PPARA | Q07869 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17899836 | 0.73 | SLC22A12 (0.55) | SLC22A12PPARAPPARGKDM4EHTT | |
| SCHEMBL3372165 | 0.72 | PPARA (0.50) | SLC22A12PPARAPPARGTSHRKDM4E | |
| SCHEMBL31359592 | 0.69 | CYP2A6 (0.50) | KDM4EHTTHSD17B10ALDH1A1CYP2A6 | |
| SCHEMBL10924024 | 0.67 | CYP3A4 (0.44) | MKNK1MKNK2KDM4EKMOHTT | |
| SCHEMBL20255018 | 0.66 | LMNA (0.46) | MKNK1MKNK2PPARAKDM4EKMO | |
| SCHEMBL23871139 | 0.65 | PPARA (0.55) | PPARAPPARGKDM4EHSD17B10PPARD | |
| Pivalate SCHEMBL27910502 | 0.64 | CYP2A6 (0.50) | SLC22A12MKNK1MKNK2KMOKIF11 | |
| SCHEMBL11063546 | 0.64 | PPARA (0.56) | PPARAPPARG | |
| SCHEMBL23830218 | 0.64 | MKNK1 (0.46) | MKNK1MKNK2GPR35KDM4EKMO | |
| SCHEMBL14327641 | 0.64 | CYP2A6 (0.52) | MKNK1MKNK2KDM4EHTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4178672-A1 | MODULATORS OF THR-ß AND METHODS OF USE THEREOF | Aligos Therapeutics, Inc. (US) | 2023-05-17 | — | — | EP | disclosed |