Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 8/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.40 |
| ▸ | KDR | P35968 | 6/20 | 0.40 |
| ▸ | INSR | P06213 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 3/20 | 0.39 |
| ▸ | PAK4 | O96013 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30353151 | 0.80 | MEN1 (0.43) | MEN1HTTKMT2AHSD17B10IGF1R | |
| SCHEMBL30353140 | 0.72 | MEN1 (0.40) | MEN1HTTKMT2AHSD17B10IGF1R | |
| SCHEMBL30353156 | 0.69 | MEN1 (0.44) | MEN1HTTKMT2AHSD17B10IGF1R | |
| SCHEMBL18154671 | 0.69 | MEN1 (0.47) | MEN1HTTKMT2AHSD17B10IGF1R | |
| SCHEMBL14771711 | 0.69 | PLK4 (0.55) | MEN1HTTKMT2AHSD17B10IGF1R | |
| SCHEMBL30353148 | 0.69 | MEN1 (0.47) | MEN1HTTKMT2AHSD17B10IGF1R | |
| SCHEMBL16356862 | 0.68 | AURKA (0.50) | IGF1RFGFR1KDRAURKASRC | |
| SCHEMBL30353129 | 0.68 | MEN1 (0.40) | MEN1HTTKMT2AHSD17B10IGF1R | |
| SCHEMBL802014 | 0.67 | AURKA (0.65) | AURKASRCGSK3BJAK2JAK3 | |
| SCHEMBL14771762 | 0.67 | AURKA (0.51) | MEN1HTTKMT2AHSD17B10IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11612604-B2 | Methods of treating cancer with PLK4 inhibitors | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (CH) | 2023-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11612604-B2 | Methods of treating cancer with PLK4 inhibitors | PLK4, PLK2, PLK3 | MEN1 3546/4885HTT 3372/4885KMT2A 1059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.