Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 6/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | MC5R | P33032 | 1/20 | 0.30 |
| ▸ | MC3R | P41968 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31019941 | 0.75 | MC4R (0.40) | MC4RPDE3BPDE3AMC5RMC3R | |
| SCHEMBL30355174 | 0.73 | MC4R (0.46) | MC4RPDE3BPDE3AMC5RMC3R | |
| SCHEMBL24094565 | 0.71 | MC4R (0.47) | MC4RPDE3BPDE3AMC5RMC3R | |
| SCHEMBL30323413 | 0.71 | MC4R (0.47) | MC4RPDE3BPDE3AMC5RMC3R | |
| Hydrochloric Acid SCHEMBL30184821 | 0.70 | MC4R (0.47) | MC4RPDE3BPDE3AMC5RMC3R | |
| Hydrochloric Acid SCHEMBL31099030 | 0.70 | MC4R (0.47) | MC4RPDE3BPDE3AMC5RMC3R | |
| SCHEMBL31019945 | 0.70 | MC4R (0.44) | MC4RMC5RMC3RKCNH2 | |
| SCHEMBL30355149 | 0.69 | NNMT (0.41) | MC4RPDE3BPDE3AMC5RMC3R | |
| Hydrochloric Acid SCHEMBL31099090 | 0.67 | MC4R (0.45) | MC4RPDE3BPDE3AMC5RMC3R | |
| Hydrochloric Acid SCHEMBL31099031 | 0.67 | MC4R (0.45) | MC4RPDE3BPDE3AMC5RMC3R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161927-A1 | SPIRO COMPOUNDS AS MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | Pfizer Inc. (US) | 2023-04-12 | — | — | EP | disclosed |