Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1657919 | 1.00 | ACSS2 (0.46) | ACSS2MAPTALDH1A1CA1CA2 | |
| SCHEMBL13199189 | 0.89 | ACSS2 (0.51) | ACSS2MAPTALDH1A1CA1CA2 | |
| SCHEMBL23005428 | 0.87 | ALDH1A1 (0.43) | MAPTALDH1A1CA1CA2CA5A | |
| SCHEMBL2012390 | 0.84 | ACSS2 (0.48) | ACSS2MAPTNPSR1KDM4EPOLB | |
| SCHEMBL31306494 | 0.84 | NPSR1 (0.50) | ACSS2MAPTALDH1A1NPSR1KDM4E | |
| SCHEMBL30628323 | 0.84 | ACSS2 (0.48) | ACSS2MAPTNPSR1KDM4EPOLB | |
| SCHEMBL421400 | 0.83 | CNR2 (0.47) | MAPTALDH1A1KDM4EHPGDMAPK1 | |
| SCHEMBL17420520 | 0.83 | ACSS2 (0.47) | ACSS2MAPTALDH1A1CA1CA2 | |
| SCHEMBL18982714 | 0.83 | ALDH1A1 (0.45) | MAPTALDH1A1NPSR1KDM4EHPGD | |
| SCHEMBL17420423 | 0.83 | POLB (0.51) | ACSS2MAPTALDH1A1NPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117561258-A | Novel substituted tricyclic aza heterocycles as SOS1 inhibitors | 唯久生物技术(苏州)有限公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-116041344-A | Bicyclic heteroaryl carboxamide compounds as SOS1 inhibitors | 北京望实智慧科技有限公司 | 2023-05-02 | — | — | CN | disclosed |