Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.53 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.38 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11777276 | 0.87 | CHRNB2 (0.46) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL3335936 | 0.79 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL3330896 | 0.79 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL30359051 | 0.77 | HTT (0.51) | KDM1A | |
| SCHEMBL30359168 | 0.74 | ALDH1A1 (0.49) | KDM4EKDM1A | |
| SCHEMBL31581057 | 0.74 | CCNC (0.54) | — | |
| SCHEMBL30359139 | 0.73 | PIK3CD (0.47) | PIK3CDCYP2C9CYP2C19 | |
| SCHEMBL30359097 | 0.73 | MEN1 (0.45) | KDM4ECYP2C9CYP2C19 | |
| SCHEMBL30359193 | 0.73 | CNR2 (0.43) | CHRNB2CHRNA4CHRNA3KDM1ACHRNB3 | |
| SCHEMBL3528872 | 0.73 | CHRNB2 (0.53) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116057057-A | Conjugates of alpha 2-adrenoceptor subtype C (alpha-2C) antagonists and TASK1/3 channel blockers for the treatment of sleep apnea | 拜耳公司 | 2023-05-02 | — | — | CN | disclosed |