Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.31 |
| ▸ | CDK2 | P24941 | 3/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21541827 | 1.00 | MET (0.36) | METSCN9AS1PR1CLK2LRRK2 | |
| SCHEMBL30359447 | 0.92 | MET (0.35) | METSCN9AS1PR1CLK2LRRK2 | |
| SCHEMBL21541886 | 0.92 | MET (0.35) | METSCN9AS1PR1CLK2LRRK2 | |
| SCHEMBL21541836 | 0.91 | S1PR1 (0.33) | S1PR1GPR119CCNA2CDK2CCNA1 | |
| SCHEMBL29559929 | 0.91 | S1PR1 (0.33) | S1PR1GPR119CCNA2CDK2CCNA1 | |
| SCHEMBL21541913 | 0.88 | PRKDC (0.38) | METHDAC1HDAC8HDAC6 | |
| SCHEMBL30359433 | 0.88 | PRKDC (0.38) | METHDAC1HDAC8HDAC6 | |
| SCHEMBL21541857 | 0.88 | CDK4 (0.35) | METSCN9AS1PR1CLK2LRRK2 | |
| SCHEMBL21541763 | 0.83 | CCNA2 (0.34) | S1PR1CCNA2CDK2CCNA1CDK4 | |
| SCHEMBL29559089 | 0.83 | CCNA2 (0.34) | S1PR1CCNA2CDK2CCNA1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110167941-B | Substituted fused heteroaryl compounds as kinase inhibitors and uses thereof | 上海瑛派药业有限公司 | 2023-04-04 | — | — | CN | claimed |
| CN-110167941-B | Substituted fused heteroaryl compounds as kinase inhibitors and uses thereof | 上海瑛派药业有限公司 | 2023-04-04 | — | — | CN | disclosed |