Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 7/20 | 0.34 |
| ▸ | CDK2 | P24941 | 7/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.34 |
| ▸ | PIM1 | P11309 | 4/20 | 0.34 |
| ▸ | CDK4 | P11802 | 4/20 | 0.33 |
| ▸ | CCND3 | P30281 | 4/20 | 0.33 |
| ▸ | GSK3B | P49841 | 4/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21541763 | 1.00 | CCNA2 (0.34) | CCNA2CDK2CCNA1PIM1CDK4 | |
| SCHEMBL29559929 | 0.92 | S1PR1 (0.33) | CCNA2CDK2CCNA1PIM1CDK4 | |
| SCHEMBL21541836 | 0.92 | S1PR1 (0.33) | CCNA2CDK2CCNA1PIM1CDK4 | |
| SCHEMBL21541886 | 0.91 | MET (0.35) | CCNA2CDK2CCNA1PIM1CDK4 | |
| SCHEMBL30359447 | 0.91 | MET (0.35) | CCNA2CDK2CCNA1PIM1CDK4 | |
| SCHEMBL21541807 | 0.91 | MELK (0.33) | PIM1WDR5 | |
| SCHEMBL30359448 | 0.91 | MELK (0.33) | PIM1WDR5 | |
| SCHEMBL21541779 | 0.90 | CDK4 (0.35) | CCNA2CDK2CCNA1PIM1CDK4 | |
| SCHEMBL29558902 | 0.90 | CDK4 (0.35) | CCNA2CDK2CCNA1PIM1CDK4 | |
| SCHEMBL21541852 | 0.88 | PRKDC (0.39) | PIM1WDR5MTORPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110167941-B | Substituted fused heteroaryl compounds as kinase inhibitors and uses thereof | 上海瑛派药业有限公司 | 2023-04-04 | — | — | CN | claimed |
| CN-110167941-B | Substituted fused heteroaryl compounds as kinase inhibitors and uses thereof | 上海瑛派药业有限公司 | 2023-04-04 | — | — | CN | disclosed |
| EP-3567041-A9 | SUBSTITUTED FUSED HETEROARYL COMPOUND SERVING AS A KINASE INHIBITOR, AND APPLICATIONS THEREOF | Impact Therapeutics (Shanghai), Inc (CN) | 2022-04-20 | — | — | EP | disclosed |