Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 4/20 | 0.33 |
| ▸ | BRD4 | O60885 | 4/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | BRD2 | P25440 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.32 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21541807 | 1.00 | MELK (0.33) | MELKJAK2BRD4FFAR4JAK1 | |
| SCHEMBL30359401 | 0.92 | FFAR4 (0.34) | FFAR4DYRK1ASYKWDR5 | |
| SCHEMBL21541801 | 0.92 | FFAR4 (0.34) | FFAR4DYRK1ASYKWDR5 | |
| SCHEMBL29559089 | 0.91 | CCNA2 (0.34) | PIM1WDR5 | |
| SCHEMBL21541763 | 0.91 | CCNA2 (0.34) | PIM1WDR5 | |
| SCHEMBL21541749 | 0.89 | CSF1R (0.37) | MELKJAK2BRD4FFAR4DYRK1A | |
| SCHEMBL30359436 | 0.87 | PRKDC (0.40) | MELKCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21541757 | 0.87 | PRKDC (0.40) | MELKCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL27123798 | 0.87 | PRKDC (0.40) | MELKCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21541836 | 0.83 | S1PR1 (0.33) | PIM1WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110167941-B | Substituted fused heteroaryl compounds as kinase inhibitors and uses thereof | 上海瑛派药业有限公司 | 2023-04-04 | — | — | CN | claimed |
| CN-110167941-B | Substituted fused heteroaryl compounds as kinase inhibitors and uses thereof | 上海瑛派药业有限公司 | 2023-04-04 | — | — | CN | disclosed |