Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 4/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 8/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.38 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.38 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.38 |
| ▸ | IL2 | P60568 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26516706 | 1.00 | FYN (0.51) | FYNTGFBR1ACVR1KCNH2TLR9 | |
| SCHEMBL26120751 | 0.95 | FYN (0.49) | FYNTGFBR1ACVR1KCNH2TLR9 | |
| SCHEMBL30360604 | 0.95 | FYN (0.49) | FYNTGFBR1ACVR1KCNH2TLR9 | |
| SCHEMBL30475493 | 0.92 | FYN (0.50) | FYNTGFBR1ACVR1KCNH2TLR9 | |
| SCHEMBL26516537 | 0.89 | FYN (0.53) | FYNTGFBR1ACVR1KCNH2TLR9 | |
| SCHEMBL26516612 | 0.85 | MAP4K1 (0.49) | FYNTGFBR1ACVR1KCNH2TLR9 | |
| SCHEMBL26516919 | 0.80 | FYN (0.43) | FYNTGFBR1ACVR1KCNH2MAP4K1 | |
| SCHEMBL26516610 | 0.79 | TLR8 (0.55) | FYNTGFBR1ACVR1TLR9TLR8 | |
| SCHEMBL26516625 | 0.77 | TGFBR1 (0.63) | FYNTGFBR1ACVR1TLR9TLR8 | |
| SCHEMBL30360601 | 0.76 | MAP4K1 (0.47) | FYNACVR1MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115956077-A | Substituted heteroaryl compounds as TLR9 inhibitors | 百时美施贵宝公司 | 2023-04-11 | — | — | CN | claimed |
| EP-4200015-A1 | SUBSTITUTED HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | Bristol-Myers Squibb Company (US) | 2023-06-28 | — | — | EP | disclosed |
| CN-115956077-A | Substituted heteroaryl compounds as TLR9 inhibitors | 百时美施贵宝公司 | 2023-04-11 | — | — | CN | disclosed |