Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 4/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26516729 | 1.00 | ACVR1 (0.41) | ACVR1FYNMAP4K1HRH3PIK3CD | |
| SCHEMBL26516639 | 0.90 | ACVR1 (0.50) | ACVR1FYNMAP4K1HRH3PIK3CD | |
| SCHEMBL30360624 | 0.90 | ACVR1 (0.50) | ACVR1FYNMAP4K1HRH3PIK3CD | |
| SCHEMBL26516741 | 0.87 | ACVR1 (0.40) | ACVR1FYNMAP4K1PIK3CBSYK | |
| SCHEMBL30360622 | 0.87 | ACVR1 (0.40) | ACVR1FYNMAP4K1PIK3CBSYK | |
| SCHEMBL26516557 | 0.83 | MAP4K1 (0.47) | ACVR1FYNMAP4K1HRH3PIK3CD | |
| SCHEMBL30360601 | 0.83 | MAP4K1 (0.47) | ACVR1FYNMAP4K1HRH3PIK3CD | |
| SCHEMBL26516919 | 0.79 | FYN (0.43) | ACVR1FYNMAP4K1HRH3SYK | |
| SCHEMBL26516537 | 0.77 | FYN (0.53) | ACVR1FYNMAP4K1 | |
| SCHEMBL30360607 | 0.76 | MAP4K1 (0.41) | ACVR1FYNMAP4K1HRH3PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4200015-A1 | SUBSTITUTED HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | Bristol-Myers Squibb Company (US) | 2023-06-28 | — | — | EP | claimed |
| CN-115956077-A | Substituted heteroaryl compounds as TLR9 inhibitors | 百时美施贵宝公司 | 2023-04-11 | — | — | CN | claimed |