Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 7/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 7/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | PTGIR | P43119 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | FRK | P42685 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30361925 | 0.88 | S1PR1 (0.37) | PTGS2S1PR1ABCC1ABCG2ABCB1 | |
| SCHEMBL30361895 | 0.87 | PDE10A (0.40) | PTGS2S1PR1PDE10A | |
| SCHEMBL30361897 | 0.87 | PTGS2 (0.38) | PTGS2S1PR1PDE10AFAAHPTGIR | |
| SCHEMBL30362058 | 0.85 | S1PR1 (0.40) | PTGS2S1PR1FAAHADORA1EGFR | |
| SCHEMBL30361987 | 0.84 | S1PR1 (0.44) | PTGS2S1PR1FAAHADORA1EGFR | |
| SCHEMBL26134351 | 0.82 | EGFR (0.40) | PTGS2ABCC1ABCG2ABCB1EGFR | |
| SCHEMBL30362041 | 0.79 | S1PR1 (0.34) | PTGS2S1PR1 | |
| SCHEMBL30362033 | 0.77 | ACVR1 (0.37) | PTGS2S1PR1FAAH | |
| SCHEMBL30361899 | 0.77 | ACVR1 (0.37) | PTGS2S1PR1FAAH | |
| SCHEMBL30362051 | 0.77 | ACVR1 (0.37) | PTGS2S1PR1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023076849-A1 | INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR | ORIC PHARMACEUTICALS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |