Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | IDH1 | O75874 | 2/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | TOP1 | P11387 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26092204 | 1.00 | PRF1 (0.50) | PRF1MEN1KMT2AIDH1CSNK2A2 | |
| SCHEMBL26092915 | 0.77 | MEN1 (0.67) | MEN1KMT2AIDH1CSNK2A2CLK1 | |
| SCHEMBL24904485 | 0.75 | MEN1 (0.67) | PRF1MEN1KMT2AIDH1CSNK2A2 | |
| SCHEMBL5571316 | 0.75 | PIM1 (0.34) | MEN1KMT2ACSNK2A2CLK1CSNK2B | |
| SCHEMBL30363450 | 0.73 | CSNK2A2 (0.64) | PRF1MEN1KMT2AIDH1CSNK2A2 | |
| SCHEMBL24904264 | 0.73 | CSNK2A2 (0.64) | PRF1MEN1KMT2AIDH1CSNK2A2 | |
| SCHEMBL5570154 | 0.71 | PIM1 (0.40) | MEN1KMT2ACSNK2A2CLK1CSNK2B | |
| SCHEMBL5571315 | 0.71 | TRPM5 (0.32) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL4658846 | 0.70 | KMT2A (0.60) | MEN1KMT2AIDH1CSNK2A2CLK1 | |
| SCHEMBL4658847 | 0.70 | KMT2A (0.60) | MEN1KMT2AIDH1CSNK2A2CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4422747-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023072969-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | disclosed |