Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | CLK1 | P49759 | 2/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.36 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30363413 | 0.71 | PRF1 (0.50) | PIM1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL26092204 | 0.71 | PRF1 (0.50) | PIM1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL5571316 | 0.70 | PIM1 (0.34) | PIM1PIK3CDCSNK2A2PIK3CAPIK3CG | |
| SCHEMBL27794596 | 0.70 | ALDH1A1 (0.56) | TRPM5NPC1RAB9AALDH1A1CYP3A4 | |
| SCHEMBL1224754 | 0.70 | ALDH1A1 (0.56) | TRPM5NPC1RAB9AALDH1A1CYP3A4 | |
| SCHEMBL5571315 | 0.69 | TRPM5 (0.32) | PIM1PIK3CDCSNK2A2PIK3CAPIK3CG | |
| SCHEMBL27917394 | 0.67 | ALDH1A1 (0.45) | TRPM5NPC1RAB9AALDH1A1CYP3A4 | |
| SCHEMBL899929 | 0.67 | ALDH1A1 (0.45) | TRPM5NPC1RAB9AALDH1A1CYP3A4 | |
| SCHEMBL29027447 | 0.66 | ALDH1A1 (0.41) | TRPM5NPC1RAB9AALDH1A1CYP3A4 | |
| SCHEMBL3833547 | 0.66 | GSK3B (0.54) | MAPK1NPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805174-A1 | 1,5-NAPHTHYRIDINE AZOLIDINONES HAVING CDK1 ANTIPROLIFERATIVE ACTIVITY | F.HOFFMANN-LA ROCHE AG (CH) | 2007-07-11 | — | — | EP | claimed |
| WO-2006040052-A1 | 1,5-NAPHTHYRIDINE AZOLIDINONES HAVING CDK1 ANTIPROLIFERATIVE ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2006-04-20 | — | — | WO | claimed |